Mobile Geographic Information Systems (GIS) for Humanitarian Demining

The threat of landmines and other explosive remnants of war is a serious concern around the world. While landmines demand attention due to the thousands of civilian casualties they cause each year, perhaps even more shocking is the fear they instill in local populations, inhibiting movement and denying access to thousands of square kilometers of land in more than 80 countries. Humanitarian demining seeks to rid the world of landmines and return local populations to their displaced land. To meet this goal, surveys of hazardous areas, describing their location and contents, are used to produce threat maps for a given location and secure adequate funding from donor organizations for clearance operations. The focus of this study is a mobile GIS system, developed by the Geneva International Centre for Humanitarian Demining (GICHD), which allows rapid, accurate, and completely digital collection of these demining surveys. Using data collected during local evaluations of the demining Survey Tool at the University of Kansas campus and on foreign field deployments in Chile (2004), Albania (2004), Ecuador (2004), and Lebanon (2006), a fit-for-use analysis was performed on each component of the Survey Tool. Experiments were conducted to evaluate the accuracy of its GPS and laser rangefinder mapping devices, and methods for improving that accuracy were investigated. The system was well received by all of its users and gauged to be twice as fast, require half the personnel, and provide higher levels of accuracy than traditional methods for collecting demining surveys. Even though the system was deemed fit for use, suggestions for improving all components of the device resulted from user feedback and observations of the system in the field. The system's GPS receiver was predicted to provide 5 m accuracy 50 % of the time and 10 m accuracy 95 % of the time. If GPS positions were averaged for 1 minute, the 95% accuracy improved to 7.5 m, and if positions were averaged for 4 minutes, the 95% accuracy improved to 5.6 m. The two types of laser rangefinders used by the system were found to have a mean accuracy of 2.7 m when shooting at a location on the horizontal bare earth and a mean accuracy of 1.1 m when shooting at a well defined vertical target. Rangefinder accuracy varied due to level of user experience with rangefinders or other sighting equipment, and thus proved the value of training with these devices. Also, significant errors in bearing measurements with the rangefinders caused by magnetic interference from one user's eye glasses indicated that this issue requires considerable attention by all users of laser rangefinder devices. General themes that were found to be extremely important to the success of the demining system, such as the value of training, the need for system flexibility to match traditional field methods, and the complexities of GIS data collection in the field, should be a focus of any mobile GIS field program

Local Health Department Provision of WIC Services Relative to Local “Need”— Examining 3 States and 5 Years

Great variation exists in the nature of LHD service delivery and it varies, in part, relative to jurisdiction population size. Larger LHD jurisdictions may achieve an economy of scale in WIC service delivery that is not matched in smaller areas. Overall, we found that WIC service provision appears relatively consistent across study states and in the presence of increasing need, with greater responsiveness to need in urban areas. As demand for some preventive services increases LHDs in rural areas may need greater support than LHDs in large jurisdictions for meeting local demand. Unlike WIC, LHD-provided services that have less consistently maintained service-delivery guidelines may have a harder time responding to increasing need. The relative consistency of a federally-funded program such as WIC may serve as a good baseline for further study of less consistently delivered programs among LHDs. LHD service statistics can serve as useful data sources in measuring volume of service delivery relative to need

Illinois State University University Band Symphonic Band

Center for the Performing Arts Wednesday Evening April 23, 2003 8:00p.m

Climate Variability and Local Environmental Stressors Influencing Migration in Nang Rong, Thailand

Scholars point to climate change, often in the form of more frequent and severe drought, as a potential driver of migration in the developing world, particularly in populations that rely on agriculture for their livelihoods. To date, however, there have been few large-scale, longitudinal studies that explore the relationship between climate change and migration. This study significantly extends current scholarship by evaluating distinctive effects of slow onset climate change and short-term extreme events upon different migration outcomes. Our analysis models the effect of the environment--as measured by Normalized Difference Vegetation Index (NDVI) and the occurrence of El Nino Southern Oscillation (ENSO) events—on migration out of Nang Rong. Our preliminary findings indicate that predominantly dry El Niño periods of 24 months duration lead to outmigration, while predominantly wetter La Niña periods of 12-month duration reduce outmigration. Clustered monthly patterns of annual NDVI fluctuation indicate that villagers living in pixels that exhibit early, consistently higher, and steep rising green-up are less likely to migrate out in the subsequent year

Vertical structure, seasonal drawdown, and net community production in the Ross Sea, Antarctica

We calculate net community production (NCP) during summer 2005-2006 and spring 2006 in the Ross Sea using multiple approaches to determine the magnitude and consistency of rates. Water column carbon and nutrient inventories and surface ocean O-2/Ar data are compared to satellite-derived primary productivity (PP) estimates and C-14 uptake experiments. In spring, NCP was related to stratification proximal to upper ocean fronts. In summer, the most intense C drawdown was in shallow mixed layers affected by ice melt; depth-integrated C drawdown, however, increased with mixing depth. Delta O-2/Ar-based methods, relying on gas exchange reconstructions, underestimate NCP due to seasonal variations in surface Delta O-2/Ar and NCP rates. Mixed layer Delta O-2/Ar requires approximately 60 days to reach steady state, starting from early spring. Additionally, cold temperatures prolong the sensitivity of gas exchange reconstructions to past NCP variability. Complex vertical structure, in addition to the seasonal cycle, affects interpretations of surface-based observations, including those made from satellites. During both spring and summer, substantial fractions of NCP were below the mixed layer. Satellite-derived estimates tended to overestimate PP relative to C-14-based estimates, most severely in locations of stronger upper water column stratification. Biases notwithstanding, NCP-PP comparisons indicated that community respiration was of similar magnitude to NCP. We observed that a substantial portion of NCP remained as suspended particulate matter in the upper water column, demonstrating a lag between production and export. Resolving the dynamic physical processes that structure variance in NCP and its fate will enhance the understanding of the carbon cycling in highly productive Antarctic environments

Sand in the wheels, or oiling the wheels, of international finance? : New Labour's appeal to a 'new Bretton Woods'

Tony Blair’s political instinct typically is to associate himself only with the future. As such, his explicit appeal to ‘the past’ in his references to New Labour’s desire to establish a “new Bretton Woods” is sufficient in itself to arouse some degree of analytical curiosity (see Blair 1998a). The fact that this appeal was made specifically in relation to Bretton Woods is even more interesting. The resonant image of the international economic context established by the original Bretton Woods agreements invokes a style and content of policy-making which Tony Blair typically dismisses as neither economically nor politically consistent with his preferred vision of the future (see Blair 2000c, 2001b)

Pulmonary-to-Systemic Arterial Shunt to Treat Children With Severe Pulmonary Hypertension

BACKGROUND: The placement of a pulmonary-to-systemic arterial shunt in children with severe pulmonary hypertension (PH) has been demonstrated, in relatively small studies, to be an effective palliation for their disease. OBJECTIVES: The aim of this study was to expand upon these earlier findings using an international registry for children with PH who have undergone a shunt procedure. METHODS: Retrospective data were obtained from 110 children with PH who underwent a shunt procedure collected from 13 institutions in Europe and the United States. RESULTS: Seventeen children died in-hospital postprocedure (15%). Of the 93 children successfully discharged home, 18 subsequently died or underwent lung transplantation (20%); the mean follow-up was 3.1 years (range: 25 days to 17 years). The overall 1- and 5-year freedom from death or transplant rates were 77% and 58%, respectively, and 92% and 68% for those discharged home, respectively. Children discharged home had significantly improved World Health Organization functional class (P < 0.001), 6-minute walk distances (P = 0.047) and lower brain natriuretic peptide levels (P < 0.001). Postprocedure, 59% of children were weaned completely from their prostacyclin infusion (P < 0.001). Preprocedural risk factors for dying in-hospital postprocedure included intensive care unit admission (hazard ratio [HR]: 3.2; P = 0.02), mechanical ventilation (HR: 8.3; P < 0.001) and extracorporeal membrane oxygenation (HR: 10.7; P < 0.001). CONCLUSIONS: A pulmonary-to-systemic arterial shunt can provide a child with severe PH significant clinical improvement that is both durable and potentially free from continuous prostacyclin infusion. Five-year survival is comparable to children undergoing lung transplantation for PH. Children with severely decompensated disease requiring aggressive intensive care are not good candidates for the shunt procedure

Cluster M Mycobacteriophages Bongo, PegLeg, and Rey with Unusually Large Repertoires of tRNA Isotopes

Genomic analysis of a large set of phages infecting the common hostMycobacterium smegmatis mc2155 shows that they span considerable genetic diversity. There are more than 20 distinct types that lack nucleotide similarity with each other, and there is considerable diversity within most of the groups. Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, and Rey, constitute a new group (cluster M), with the closely related phages Bongo and PegLeg forming subcluster M1 and the more distantly related Rey forming subcluster M2. The cluster M mycobacteriophages have siphoviral morphologies with unusually long tails, are homoimmune, and have larger than average genomes (80.2 to 83.7 kbp). They exhibit a variety of features not previously described in other mycobacteriophages, including noncanonical genome architectures and several unusual sets of conserved repeated sequences suggesting novel regulatory systems for both transcription and translation. In addition to containing transfer-messenger RNA and RtcB-like RNA ligase genes, their genomes encode 21 to 24 tRNA genes encompassing complete or nearly complete sets of isotypes. We predict that these tRNAs are used in late lytic growth, likely compensating for the degradation or inadequacy of host tRNAs. They may represent a complete set of tRNAs necessary for late lytic growth, especially when taken together with the apparent lack of codons in the same late genes that correspond to tRNAs that the genomes of the phages do not obviously encode

FLT3 mutations in canine acute lymphocytic leukemia

<p>Abstract</p> <p>Background</p> <p>FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, and a poorer prognosis. A better understanding of the molecular consequences of FLT3 activation would allow improved therapeutic strategies in these patients. Canine lymphoproliferative diseases, including lymphoma and acute leukemias, share evolutionarily conserved chromosomal aberrations and exhibit conserved mutations within key oncogenes when compared to their human counterparts. A small percentage of canine acute lymphocytic leukemias (ALL) also exhibit <it>FLT3 </it>ITD mutations.</p> <p>Methods</p> <p>We molecularly characterized <it>FLT3 </it>mutations in two dogs and one cell line, by DNA sequencing, gene expression analysis via quantitative real-time PCR, and sensitivity to the FLT3 inhibitor lestaurtinib via <it>in vitro </it>proliferation assays. FLT 3 and downstream mediators of FLT3 activation were assessed by Western blotting.</p> <p>Results</p> <p>The canine B-cell leukemia cell line, GL-1, and neoplastic cells from 2/7 dogs diagnosed cytologically with ALL were found to have <it>FLT3 </it>ITD mutations and <it>FLT3 </it>mRNA up-regulation. Lestaurtinib, a small molecule FLT3 inhibitor, significantly inhibited the growth of GL-1 cells, while not affecting the growth of two other canine lymphoid cell lines without the <it>FLT3 </it>mutation. Finally, western blots were used to confirm the conserved downstream mediators of <it>FLT3 </it>activating mutations.</p> <p>Conclusions</p> <p>These results show that ALL and FLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias.</p